Open AccessDeciphering Functions of Branched Ubiquitin Chains
Author(s) -
Jaime López-Mosqueda,
Ivan Đikić
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.04.026
Subject(s) - biology , ubiquitin , computational biology , ubiquitin protein ligases , genetics , ubiquitin ligase , microbiology and biotechnology , evolutionary biology , gene
The anaphase-promoting complex/cyclosome targets proteins for degradation by catalyzing homotypic ubiquitin chains of different linkage types. In this issue of Cell, Meyer and Rape diversify the degradation signals by demonstrating that the APC/C and its cognate E2 conjugating enzymes enhance the rate of substrate degradation by decorating them with branched Lys11 and Lys48 ubiquitin chains.
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