Programming and Inheritance of Parental DNA Methylomes in Mammals | Zendy

Lu Wang | Zendy; Jun Zhang | Zendy; Jialei Duan | Zendy; Xinxing Gao | Zendy; Wei Zhu | Zendy; Xingyu Lu | Zendy; Lu Yang | Zendy; Jing Zhang | Zendy; Guoqiang Li | Zendy; Weimin Ci | Zendy; Wei Li | Zendy; Qi Zhou | Zendy; Neel Aluru | Zendy; Fuchou Tang | Zendy; Chuan He | Zendy; Xingxu Huang | Zendy; Jiang Liu | Zendy

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Programming and Inheritance of Parental DNA Methylomes in Mammals

Author(s) -

Lu Wang,

Jun Zhang,

Jialei Duan,

Xinxing Gao,

Wei Zhu,

Xingyu Lu,

Lu Yang,

Jing Zhang,

Guoqiang Li,

Weimin Ci,

Wei Li,

Qi Zhou,

Neel Aluru,

Fuchou Tang,

Chuan He,

Xingxu Huang,

Jiang Liu

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.04.017

Subject(s) - biology , reprogramming , dna demethylation , dna methylation , genomic imprinting , epigenetics , genetics , imprinting (psychology) , somatic cell , germline , germ cell , embryo , inheritance (genetic algorithm) , embryonic stem cell , methylation , allele , 5 hydroxymethylcytosine , dna , cell , gene , gene expression

The reprogramming of parental methylomes is essential for embryonic development. In mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted to oxidized bases. These paternal oxidized bases and maternal 5mCs are believed to be passively diluted by cell divisions. By generating single-base resolution, allele-specific DNA methylomes from mouse gametes, early embryos, and primordial germ cell (PGC), as well as single-base-resolution maps of oxidized cytosine bases for early embryos, we report the existence of 5hmC and 5fC in both maternal and paternal genomes and find that 5mC or its oxidized derivatives, at the majority of demethylated CpGs, are converted to unmodified cytosines independent of passive dilution from gametes to four-cell embryos. Therefore, we conclude that paternal methylome and at least a significant proportion of maternal methylome go through active demethylation during embryonic development. Additionally, all the known imprinting control regions (ICRs) were classified into germ-line or somatic ICRs.

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