Mechanisms and Functions of Inflammasomes | Zendy

Mohamed Lamkanfi | Zendy; Vishva M. Dixit | Zendy

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Mechanisms and Functions of Inflammasomes

Author(s) -

Mohamed Lamkanfi,

Vishva M. Dixit

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.04.007

Subject(s) - pyroptosis , inflammasome , proinflammatory cytokine , caspase , biology , lytic cycle , caspase 1 , microbiology and biotechnology , programmed cell death , secretion , immunology , apoptosis , inflammation , genetics , biochemistry , virus

Recent studies have offered a glimpse into the sophisticated mechanisms by which inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18. Activation of caspases 1 and 11 in canonical and noncanonical inflammasomes, respectively, also protects against infection by triggering pyroptosis, a proinflammatory and lytic mode of cell death. The therapeutic potential of inhibiting these proinflammatory caspases in infectious and autoimmune diseases is raised by the successful deployment of anti-IL-1 therapies to control autoinflammatory diseases associated with aberrant inflammasome signaling. This Review summarizes recent insights into inflammasome biology and discusses the questions that remain in the field.

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