Open AccessConnect Four with Glioblastoma Stem Cell Factors
Author(s) -
Jan Gronych,
Stefan M. Pfister,
David Jones
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.04.001
Subject(s) - biology , stem cell , glioblastoma , genetics , microbiology and biotechnology , computational biology , cancer research
Hierarchical cell state models, wherein a few stem-like tumor-propagating cells repopulate the tumor after therapy, are often invoked in cancer. Suvà et al. demonstrate a plastic developmental hierarchy in glioma cell populations by characterizing the epigenetic states of phenotypically distinct cells and identifying four factors sufficient to reprogram differentiated cells into a tumorigenic stem-like state.
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