Open AccessMultiplying Messages LRRK beneath Parkinson Disease
Author(s) -
William T. Dauer,
Ming Guo
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.03.043
Subject(s) - biology , lrrk2 , disease , parkinson's disease , mechanism (biology) , neuroscience , kinase , genetics , pathology , medicine , philosophy , epistemology
Parkinson Disease (PD) is a progressive neurodegenerative disorder with limited therapeutic options. In this issue of Cell, Martin et al. link PD protein leucine-rich repeat kinase 2 (LRRK2) to abnormalities of translational control, a pathogenic mechanism implicated in an increasing number of CNS neurodegenerative diseases, as well as in normal aging.
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