Peering into the Crystal Ball: Influenza Pandemics and Vaccine Efficacy | Zendy

Matthew S. Miller | Zendy; Peter Palese | Zendy

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Peering into the Crystal Ball: Influenza Pandemics and Vaccine Efficacy

Author(s) -

Matthew S. Miller,

Peter Palese

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.03.023

Subject(s) - pandemic , vaccination , biology , vaccine efficacy , virus , virology , looming , influenza a virus , live attenuated influenza vaccine , influenza vaccine , covid-19 , medicine , infectious disease (medical specialty) , disease , physics , pathology , optics

The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely needed in order to improve the effectiveness of influenza virus vaccines. Will new studies aimed at identifying adaptations required for virus transmissibility and systems-level analyses of influenza virus vaccine responses provide an improved framework for predictive models of viral adaptation and vaccine efficacy?

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