Nuclear Receptors, RXR, and the Big Bang | Zendy

Ronald M. Evans | Zendy; David J. Mangelsdorf | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Nuclear Receptors, RXR, and the Big Bang

Author(s) -

Ronald M. Evans,

David J. Mangelsdorf

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.03.012

Subject(s) - biology , nuclear receptor , retinoid x receptor , receptor , retinoid x receptor alpha , thyroid hormone receptor , rhodopsin like receptors , microbiology and biotechnology , genetics , gene , transcription factor , glutamate receptor , metabotropic receptor

Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan receptors. Characterization of these orphan receptors and, in particular, of the retinoid X receptor (RXR) positioned nuclear receptors at the epicenter of the "Big Bang" of molecular endocrinology. This Review provides a personal perspective on nuclear receptors and explores their integrated and coordinated signaling networks that are essential for multicellular life, highlighting the RXR heterodimer and its associated ligands and transcriptional mechanism.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research