The Fire Within: Microbes Inflame Tumors | Zendy

Nicola Gagliani | Zendy; Bo Hu | Zendy; Samuel Huber | Zendy; Eran Elinav | Zendy; Richard A. Flavell | Zendy

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The Fire Within: Microbes Inflame Tumors

Author(s) -

Nicola Gagliani,

Bo Hu,

Samuel Huber,

Eran Elinav,

Richard A. Flavell

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.03.006

Subject(s) - biology , immune system , inflammation , innate immune system , acquired immune system , homeostasis , gut flora , immunology , cancer , systems biology , computational biology , neuroscience , microbiology and biotechnology , genetics

The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions between the microbiota and the innate and adaptive immune systems and discuss their potential to lead us in new directions for understanding cancer biology and treatment.

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