SnapShot: Talin and the Modular Nature of the Integrin Adhesome | Zendy

Feng Ye | Zendy; Frédéric Lagarrigue | Zendy; Mark H. Ginsberg | Zendy

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SnapShot: Talin and the Modular Nature of the Integrin Adhesome

Author(s) -

Feng Ye,

Frédéric Lagarrigue,

Mark H. Ginsberg

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.02.048

Subject(s) - biology , integrin , modular design , microbiology and biotechnology , transmembrane protein , snapshot (computer storage) , focal adhesion , computational biology , signal transduction , receptor , genetics , computer science , operating system

Integrin αβ transmembrane heterodimers play central roles in metazoan development and physiology by mediating adhesion and by transmitting forces and biochemical signals across the plasma membrane. In this SnapShot, we present a simplified "modular" view of the integrin adhesome, centered on the talin-integrin interaction, and provide examples of how this view can help to unravel the adhesome's remarkable functional diversity and plasticity.

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