Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity | Zendy

Alejandro Sánchez Alvarado | Zendy; Shinya Yamanaka | Zendy

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Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity

Author(s) -

Alejandro Sánchez Alvarado,

Shinya Yamanaka

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.02.041

Subject(s) - multicellular organism , biology , stem cell , regeneration (biology) , cellular differentiation , process (computing) , evolutionary biology , microbiology and biotechnology , cell , genetics , computer science , gene , operating system

Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated cell. Past and recent discoveries in plants and animals, as well as novel experimental manipulations, are beginning to erode many of these established concepts and are forcing a re-evaluation of the experimental systems and paradigms presently being used to explore these and other biological process.

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