Inflammasome: Putting the Pieces Together | Zendy

Jürgen Ruland | Zendy

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Inflammasome: Putting the Pieces Together

Author(s) -

Jürgen Ruland

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.02.038

Subject(s) - inflammasome , aim2 , pyrin domain , signal transducing adaptor protein , microbiology and biotechnology , biology , innate immune system , caspase 1 , cytokine , nalp3 , inflammation , signal transduction , immunology , immune system

Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inflammasome assembly.

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