Sugarcoating ER Stress | Zendy

Lisa VincenzDonnelly | Zendy; F. Ulrich Hartl | Zendy

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Sugarcoating ER Stress

Author(s) -

Lisa VincenzDonnelly,

F. Ulrich Hartl

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.02.035

Subject(s) - endoplasmic reticulum , biology , glycosylation , unfolded protein response , serine , asparagine , cytosol , biochemistry , microbiology and biotechnology , threonine , n linked glycosylation , translocon , protein folding , glycoprotein , phosphorylation , amino acid , chromosomal translocation , enzyme , gene , glycan

The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.

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