Ribosome Rescue, Nearing the End | Zendy

Agata L. Starosta | Zendy; Daniel N. Wilson | Zendy

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Ribosome Rescue, Nearing the End

Author(s) -

Agata L. Starosta,

Daniel N. Wilson

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.02.028

Subject(s) - ribosome , biology , ribosome profiling , eukaryotic ribosome , start codon , stop codon , protein biosynthesis , five prime untranslated region , untranslated region , messenger rna , microbiology and biotechnology , internal ribosome entry site , translation (biology) , genetics , rna , gene

In eukaryotes, Dom34 is involved in the rescue of ribosomes that stall on mRNAs during protein synthesis. Using ribosome profiling, Guydosh and Green reveal that, in addition to rescue of ribosomes stalled on truncated mRNAs, Dom34 also recycles ribosomes that are unexpectedly found in the 3' untranslated regions of many cellular mRNAs.

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