Nuclear Pores Set the Speed Limit for Mitosis | Zendy

Abigail Buchwalter | Zendy; Martin W. Hetzer | Zendy

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Nuclear Pores Set the Speed Limit for Mitosis

Author(s) -

Abigail Buchwalter,

Martin W. Hetzer

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.02.004

Subject(s) - spindle checkpoint , kinetochore , mitotic exit , biology , microbiology and biotechnology , spindle apparatus , mitosis , mad2 , sister chromatids , anaphase , spindle pole body , interphase , genetics , cell cycle , cell division , cell , gene , chromosome

The spindle assembly checkpoint prevents separation of sister chromatids until each kinetochore is attached to the mitotic spindle. Rodriguez-Bravo et al. report that the nuclear pore complex scaffolds spindle assembly checkpoint signaling in interphase, providing a store of inhibitory signals that limits the speed of the subsequent mitosis.

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