Open AccessmTORC1: Turning Off Is Just as Important as Turning On
Author(s) -
Don Benjamin,
Michael N. Hall
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.01.057
Subject(s) - mtorc1 , biology , lysosome , tsc1 , tsc2 , microbiology and biotechnology , regulator , tfeb , suppressor , genetics , biochemistry , signal transduction , gene , pi3k/akt/mtor pathway , enzyme
mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
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