The TPLATE Adaptor Complex Drives Clathrin-Mediated Endocytosis in Plants | Zendy

Astrid Gadeyne | Zendy; Clara SánchezRodríguez | Zendy; Steffen Vanneste | Zendy; Simone Di Rubbo | Zendy; Henrik Zauber | Zendy; Kevin Vanneste | Zendy; Jelle Van Leene | Zendy; Nancy De Winne | Zendy; Dominique Eeckhout | Zendy; Geert Persiau | Zendy; Eveline Van De Slijke | Zendy; Bernard Cannoot | Zendy; Leen Vercruysse | Zendy; Jonathan R. Mayers | Zendy; Maciek Adamowski | Zendy; Urszula Kania | Zendy; Matthias Ehrlich | Zendy; Alois Schweighofer | Zendy; Tijs Ketelaar | Zendy; Steven Maere | Zendy; Sebastian Y. Bednarek | Zendy; Jìří Friml | Zendy; Kris Gevaert | Zendy; Erwin Witters | Zendy; Eugenia Russinova | Zendy; Staffan Persson | Zendy; Geert De Jaeger | Zendy; Daniël Van Damme | Zendy

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The TPLATE Adaptor Complex Drives Clathrin-Mediated Endocytosis in Plants

Author(s) -

Astrid Gadeyne,

Clara SánchezRodríguez,

Steffen Vanneste,

Simone Di Rubbo,

Henrik Zauber,

Kevin Vanneste,

Jelle Van Leene,

Nancy De Winne,

Dominique Eeckhout,

Geert Persiau,

Eveline Van De Slijke,

Bernard Cannoot,

Leen Vercruysse,

Jonathan R. Mayers,

Maciek Adamowski,

Urszula Kania,

Matthias Ehrlich,

Alois Schweighofer,

Tijs Ketelaar,

Steven Maere,

Sebastian Y. Bednarek,

Jìří Friml,

Kris Gevaert,

Erwin Witters,

Eugenia Russinova,

Staffan Persson,

Geert De Jaeger,

Daniël Van Damme

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.01.039

Subject(s) - endocytosis , endocytic cycle , clathrin , biology , microbiology and biotechnology , internalization , receptor mediated endocytosis , signal transducing adaptor protein , dynamin , clathrin adaptor proteins , signal transduction , biochemistry , receptor

Clathrin-mediated endocytosis is the major mechanism for eukaryotic plasma membrane-based proteome turn-over. In plants, clathrin-mediated endocytosis is essential for physiology and development, but the identification and organization of the machinery operating this process remains largely obscure. Here, we identified an eight-core-component protein complex, the TPLATE complex, essential for plant growth via its role as major adaptor module for clathrin-mediated endocytosis. This complex consists of evolutionarily unique proteins that associate closely with core endocytic elements. The TPLATE complex is recruited as dynamic foci at the plasma membrane preceding recruitment of adaptor protein complex 2, clathrin, and dynamin-related proteins. Reduced function of different complex components severely impaired internalization of assorted endocytic cargoes, demonstrating its pivotal role in clathrin-mediated endocytosis. Taken together, the TPLATE complex is an early endocytic module representing a unique evolutionary plant adaptation of the canonical eukaryotic pathway for clathrin-mediated endocytosis.

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