Mom’s Milk Molds Neural Wiring for Metabolism | Zendy

Işın Çakır | Zendy; Umut Özcan | Zendy

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Mom’s Milk Molds Neural Wiring for Metabolism

Author(s) -

Işın Çakır,

Umut Özcan

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.01.033

Subject(s) - biology , offspring , lactation , energy homeostasis , homeostasis , biological neural network , endocrinology , carbohydrate metabolism , energy metabolism , metabolism , insulin , medicine , microbiology and biotechnology , neuroscience , genetics , obesity , pregnancy

Vogt et al. demonstrate that, in mice, maternal high-fat feeding during lactation is sufficient to program the offspring for impaired energy and glucose homeostasis throughout their lifetime. They reveal that the resulting abnormal insulin signaling in the offspring interferes with the formation of hypothalamic neural circuits that contribute to metabolic status.

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