Open AccessGolgi Feels DNA’s Pain
Author(s) -
Marco Foiani,
Jiří Bártek
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.01.030
Subject(s) - golgi apparatus , biology , microbiology and biotechnology , nucleus , dna , dna damage , phosphorylation , genetics , endoplasmic reticulum
The Golgi apparatus consists of disc-like cisternae, stretching around the nucleus through forces exerted by F-actin and the Golgi membrane protein GOLPH3. Farber-Katz et al. now report that DNA damage triggers Golgi dispersal and inhibits vesicular transport through DNA-PK-mediated GOLPH3 phosphorylation, thereby linking the DNA damage response to Golgi regulation.
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