Neural Stem Cell Dissemination after Grafting to CNS Injury Sites | Zendy

Mark H. Tuszynski | Zendy; Yaozhi Wang | Zendy; Lori Graham | Zendy; Mingyong Gao | Zendy; Di Wu | Zendy; J. H. Brock | Zendy; Armin Blesch | Zendy; E Rosenzweig | Zendy; Leif A. Havton | Zendy; Binhai Zheng | Zendy; J. M. Conner | Zendy; Martin Maršala | Zendy; Paul Lu | Zendy

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Neural Stem Cell Dissemination after Grafting to CNS Injury Sites

Author(s) -

Mark H. Tuszynski,

Yaozhi Wang,

Lori Graham,

Mingyong Gao,

Di Wu,

J. H. Brock,

Armin Blesch,

E Rosenzweig,

Leif A. Havton,

Binhai Zheng,

J. M. Conner,

Martin Maršala,

Paul Lu

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.01.016

Subject(s) - biology , neural stem cell , grafting , stem cell , neuroscience , microbiology and biotechnology , chemistry , organic chemistry , polymer

Steward and colleagues report that implants of E14 rat spinal-cord-derived multipotent neural progenitor cells are associated with ectopic deposits of cells, occasionally at long distances from a T3 spinal cord lesion and grafting site. Of 20 grafted rats, half showed ectopic cell deposits. One rat had a deposit of cells in the 4th ventricle, from which relatively few axons extended into the tegmentum. Half of animals had cells within six spinal segments of the lesion site, and of these, three had deposits more distantly.

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