Open AccessBistable Parvalbumin Circuits Pivotal for Brain Plasticity
Author(s) -
Takao K. Hensch
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.12.034
Subject(s) - biology , parvalbumin , neuroscience , bistability , biological neural network , neuroplasticity , plasticity , physics , quantum mechanics , thermodynamics
Experience shapes brain function throughout life to varying degrees. In a recent issue of Nature, Donato et al. identify reversible shifts in focal parvalbumin cell state during adult learning, placing it on a mechanistic continuum with developmental critical periods. A disinhibitory microcircuit controls the plasticity switch to modulate memory formation.
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