Toward Effective Probiotics for Autism and Other Neurodevelopmental Disorders | Zendy

Jack A. Gilbert | Zendy; Rosa KrajmalnikBrown | Zendy; Dorota L. Porazinska | Zendy; Sophie Weiss | Zendy; Rob Knight | Zendy

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Toward Effective Probiotics for Autism and Other Neurodevelopmental Disorders

Author(s) -

Jack A. Gilbert,

Rosa KrajmalnikBrown,

Dorota L. Porazinska,

Sophie Weiss,

Rob Knight

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.11.035

Subject(s) - autism , biology , gut flora , context (archaeology) , autism spectrum disorder , probiotic , gut–brain axis , disease , bacteroides , bioinformatics , genetics , immunology , psychology , psychiatry , medicine , bacteria , paleontology

Hsaio and colleagues link gut microbes to autism spectrum disorders (ASD) in a mouse model. They show that ASD symptoms are triggered by compositional and structural shifts of microbes and associated metabolites, but symptoms are relieved by a Bacteroides fragilis probiotic. Thus probiotics may provide therapeutic strategies for neurodevelopmental disorders.

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