snRNA Catalysts in the Spliceosome’s Ancient Core | Zendy

Hiten D. Madhani | Zendy

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snRNA Catalysts in the Spliceosome’s Ancient Core

Author(s) -

Hiten D. Madhani

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.11.022

Subject(s) - spliceosome , biology , snrnp , rna splicing , small nuclear rna , ribozyme , intron , minor spliceosome , group i catalytic intron , group ii intron , genetics , prp24 , rna , microbiology and biotechnology , gene , non coding rna

The spliceosome, an assembly of snRNAs and proteins, catalyzes the removal of introns from premessenger RNAs. A new study identifies specific phosphates in the U2-U6 snRNA complex that position two catalytic metals. Remarkably, these correspond precisely to metal-binding phosphates in a homologous structure of Group II self-splicing introns, long proposed to be the ribozyme progenitor of spliceosome.

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