Open AccessAutophagy-Mediated Tumor Promotion
Author(s) -
Jessie Yanxiang Guo,
Bing Xia,
Eileen White
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.11.019
Subject(s) - autophagy , biology , microbiology and biotechnology , homeostasis , function (biology) , mitochondrion , cancer research , cancer , tumor promotion , tumor initiation , apoptosis , carcinogenesis , genetics
Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas.
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