Open AccessStructure Modeling Using Genetically Engineered Crosslinking
Author(s) -
Kuntal Pal,
Karsten Melcher,
H. Eric Xu
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.11.018
Subject(s) - g protein coupled receptor , receptor , biology , agonist , rhodopsin like receptors , computational biology , ligand (biochemistry) , peptide , drug discovery , microbiology and biotechnology , biochemistry , metabotropic receptor
Class B G-protein-coupled receptors are exciting drug targets, yet the structure of a complete receptor bound to a peptide agonist has remained elusive. Coin et al. present a model of the receptor CRF1R bound to its native ligand based on partial structures and 44 spatial constraints revealed by new crosslinking approaches.
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