Open AccessGlucocorticoid Rhythm Renders Female Mice More Daring
Author(s) -
Gianpaolo Rando,
Ueli Schibler
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.11.017
Subject(s) - biology , glucocorticoid , rhythm , endocrinology , medicine
Glucocorticoids, which have been implied in mood modulation, display robust diurnal oscillations in the blood. But does their circadian rhythm regulate mood swings? Ikeda et al. now identify a paracrine signaling pathway in the adrenal cortex that potentiates the daily amplitude of plasma glucocorticoids and renders female mice braver.
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