Open AccessNaked Replication Forks Break apRPArt
Author(s) -
Óscar Fernández-Capetillo,
André Nussenzweig
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.10.049
Subject(s) - biology , dna replication , replication (statistics) , dna , microbiology and biotechnology , genetics , virology
Stalled replication forks occasionally collapse, leading to potentially catastrophic DNA double-strand breaks. Now, Toledo et al. (2013) reveal that fork breakage occurs when the pool of the single-strand DNA-binding protein RPA becomes exhausted. This study has important implications for the origin and treatment of cancers with high levels of replicative stress.
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