Olfactory Control of Blood Progenitor Maintenance | Zendy

Jiwon Shim | Zendy; Tina Mukherjee | Zendy; Bama Charan Mondal | Zendy; Ting Liu | Zendy; Gloria Chin Young | Zendy; Dinali Priasha Wijewarnasuriya | Zendy; Utpal Banerjee | Zendy

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Olfactory Control of Blood Progenitor Maintenance

Author(s) -

Jiwon Shim,

Tina Mukherjee,

Bama Charan Mondal,

Ting Liu,

Gloria Chin Young,

Dinali Priasha Wijewarnasuriya,

Utpal Banerjee

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.10.032

Subject(s) - biology , progenitor cell , microbiology and biotechnology , progenitor , haematopoiesis , neuroscience , immunology , stem cell

Drosophila hematopoietic progenitor maintenance involves both near neighbor and systemic interactions. This study shows that olfactory receptor neurons (ORNs) function upstream of a small set of neurosecretory cells that express GABA. Upon olfactory stimulation, GABA from these neurosecretory cells is secreted into the circulating hemolymph and binds to metabotropic GABAB receptors expressed on blood progenitors within the hematopoietic organ, the lymph gland. The resulting GABA signal causes high cytosolic Ca(2+), which is necessary and sufficient for progenitor maintenance. Thus, the activation of an odorant receptor is essential for blood progenitor maintenance, and consequently, larvae raised on minimal odor environments fail to sustain a pool of hematopoietic progenitors. This study links sensory perception and the effects of its deprivation on the integrity of the hematopoietic and innate immune systems in Drosophila. PAPERCLIP:

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