Open Accessm6A mRNA Methylation: A New Circadian Pacesetter
Author(s) -
Michael H. Hastings
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.10.028
Subject(s) - biology , circadian rhythm , methylation , circadian clock , messenger rna , dna methylation , genetics , evolutionary biology , neuroscience , gene expression , gene
The purpose of m(6)A methylation of RNA, first observed in the 1970s, has been a longstanding mystery. Fustin et al. now show that it regulates RNA processing and determines the period and oscillatory stability of the mammalian circadian clockwork.
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