Open AccessThe Frustrated Gene: Origins of Eukaryotic Gene Expression
Author(s) -
Hiten D. Madhani
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.10.003
Subject(s) - biology , nucleic acid , gene , transcription (linguistics) , gene expression , translation (biology) , genetics , regulation of gene expression , computational biology , messenger rna , philosophy , linguistics
Eukarytotic gene expression is frustrated by a series of steps that are generally not observed in prokaryotes and are therefore not essential for the basic chemistry of transcription and translation. Their evolution may have been driven by the need to defend against parasitic nucleic acids.
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