Exploring Concentration Response in HIV Pre-Exposure Prophylaxis to Optimize Clinical Care and Trial Design | Zendy

Craig W. Hendrix | Zendy

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Exploring Concentration Response in HIV Pre-Exposure Prophylaxis to Optimize Clinical Care and Trial Design

Author(s) -

Craig W. Hendrix

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.09.030

Subject(s) - pre exposure prophylaxis , biology , clinical trial , human immunodeficiency virus (hiv) , intensive care medicine , antiretroviral therapy , immunology , viral load , bioinformatics , medicine , men who have sex with men , syphilis

HIV pre-exposure prophylaxis trials with antiretroviral drugs have been variably successful. Even trials demonstrating the best efficacy leave room for improvement. Pharmacological data illuminate several sources of outcome variability, especially the impact of poor adherence, which is critical to manage PrEP in the clinic and to develop the next generation of PrEP candidates.

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