G1 Compartmentalization and Cell Fate Coordination | Zendy

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G1 Compartmentalization and Cell Fate Coordination

Author(s) -

Stephen Dalton

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.09.015

Subject(s) - biology , endoderm , neuroectoderm , microbiology and biotechnology , cell cycle , cell fate determination , induced pluripotent stem cell , compartmentalization (fire protection) , embryonic stem cell , cell , mesoderm , genetics , biochemistry , gene , transcription factor , enzyme

Pauklin and Vallier show that, whereas early G1 is permissive for TGF-β-dependent endoderm differentiation, cyclin D restricts the activity of Smad2/3 in late G1, resulting in a switch from endoderm to neuroectoderm potential in pluripotent stem cells. These findings provide insight into how signaling, the cell cycle, and lineage specification are coordinated.

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