For Genomes to Stay in Shape, Insulators Must Be up to PAR | Zendy

Patrick J. Wijchers | Zendy; Wouter de Laat | Zendy

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For Genomes to Stay in Shape, Insulators Must Be up to PAR

Author(s) -

Patrick J. Wijchers,

Wouter de Laat

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.09.012

Subject(s) - chromatin , biology , genome , dna , ctcf , gene , insulator (electricity) , computational biology , genetics , non histone protein , genomic organization , dna binding protein , transcription factor , enhancer , physics , optoelectronics

Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.

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