FOXO in the Hole: Leveraging GWAS for Outcome and Function | Zendy

Peter K. Gregersen | Zendy; Nataly ManjarrezOrduño | Zendy

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FOXO in the Hole: Leveraging GWAS for Outcome and Function

Author(s) -

Peter K. Gregersen,

Nataly ManjarrezOrduño

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.08.050

Subject(s) - genome wide association study , biology , rheumatoid arthritis , genetic association , disease , computational biology , immunology , genetics , single nucleotide polymorphism , gene , medicine , genotype

GWAS studies of autoimmune disorders have yielded hundreds of replicated associations, but moving from genetic association to functional studies with potential clinical relevance is a challenge. Leveraging GWAS data, Lee et al. now identify FOXO3 activity as predictive of disease severity in Crohn's disease and rheumatoid arthritis as well as malaria, likely by acting through regulation of cytokine production in monocytes.

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