Open AccessSelf-Eating Limits EGFR-Dependent Tumor Growth
Author(s) -
Valeria R. Fantin,
Robert T. Abraham
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.08.040
Subject(s) - autophagy , biology , microbiology and biotechnology , context (archaeology) , tumor progression , phosphorylation , cell growth , cancer cell , cancer research , cancer , biochemistry , genetics , apoptosis , paleontology
Autophagy is a cell-autonomous, catabolic process that plays context-dependent roles in tumor growth and progression. Wei et al. report that EGFR signaling promotes tumor growth through phosphorylation and functional inactivation of Beclin 1 and the consequent suppression of autophagy.
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