Open AccessA Cluster to Remember
Author(s) -
Gerd A. Blobel,
Ross C. Hardison
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.07.041
Subject(s) - biology , transcription factor , enhancer , chromatin , cohesin , cell cycle , genetics , mitosis , transcription (linguistics) , gene , microbiology and biotechnology , linguistics , philosophy
Based on a massive transcription factor location analysis within a single cell type, in this issue Yan et al. find that the great majority of occupancies occur within dense clusters of up to 100 factors that almost invariably contain cohesins. Retention of cohesins at cluster sites during mitosis raises the possibility that they contribute to transcriptional memory during the cell cycle.
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