Open AccessA Histone Modifier’s Ill-Gotten Copy Gains
Author(s) -
Ryan Rickels,
Ali Shilatifard
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.07.010
Subject(s) - biology , demethylase , histone , copy number variation , genetics , evolutionary biology , genome , gene
Little is known about the molecular machinery that contributes to site-specific copy number variations or how CNVs fit into the chronology of tumor progression. Black et al. (2013) now demonstrate that the overexpression of a histone demethylase induces transient copy gain of specific genomic loci known to harbor proto-oncogenes.
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