Open AccessJust a Trim, Please: Refining ER Degradation through Deubiquitination
Author(s) -
Jeffrey L. Brodsky
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.07.008
Subject(s) - biology , trim , refining (metallurgy) , microbiology and biotechnology , degradation (telecommunications) , computational biology , engineering , telecommunications , chemistry , structural engineering
ER-associated degradation clears the secretory pathway of misfolded proteins and mediates the regulated degradation of some ER resident proteins. Only a minor increase in the interaction between a protein and a ubiquitin ligase is sufficient to signal substrate degradation. Zhang et al. have identified deubiquitination as a signal amplifier.
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