DNA Methylation of Transcriptional Enhancers and Cancer Predisposition | Zendy

Dvir Aran | Zendy; Asaf Hellman | Zendy

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DNA Methylation of Transcriptional Enhancers and Cancer Predisposition

Author(s) -

Dvir Aran,

Asaf Hellman

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.06.018

Subject(s) - biology , dna methylation , enhancer , genetics , dna , methylation , cancer , epigenetics , cancer research , gene , transcription factor , gene expression

Predisposition to common human diseases is frequently associated with polymorphisms in distal control regions, also known as gene enhancers. Li et al. (Li et al., 2013) evaluated the relative contributions of somatic and germline mutations to intertumor gene expression variation, with the aim of revealing links between genomic regions associated with cancer susceptibility and the expression of genes involved in cancer development. The authors assessed the contribution of DNA methylation in gene promoters to variation in intertumor gene expression and found that 3.3% of this variation can be attributed to methylation variation.

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