Aging Well with a Little Wine and a Good Clock | Zendy

William J. Belden | Zendy; Jay Dunlap | Zendy

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Aging Well with a Little Wine and a Good Clock

Author(s) -

William J. Belden,

Jay Dunlap

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.05.055

Subject(s) - biology , circadian rhythm , longevity , circadian clock , knockout mouse , period (music) , genetically modified mouse , neuroscience , transgene , microbiology and biotechnology , physiology , gerontology , genetics , medicine , receptor , physics , gene , acoustics

Age-related decline in mammalian circadian rhythm has been recognized for decades, but the underlying molecular mechanisms have remained elusive. In this issue of Cell, Chang and Guarente use brain-specific SIRT1 knockout mice and transgenic mice overexpressing SIRT1 to develop an enticing model for how SIRT1 helps maintain the robustness of the aging circadian clock.

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