Open AccessCarving Axon Arbors to Fit: Master Directs One Kinase at a Time
Author(s) -
Daisuke Satoh,
Silvia Arber
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.05.047
Subject(s) - biology , carving , axon , neuroscience , genetics , evolutionary biology , computational biology , visual arts , art
Pyramidal neurons in the cortex require the master kinase LKB1 for early axon specification. Courchet et al. now uncover a later role for LKB1 and its tango with the downstream effector kinase NUAK1 in controlling terminal axonal branching through influencing mitochondrial motility in axons.
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