Talking to Each Other to Initiate Sexual Differentiation | Zendy

Hernando A. del Portillo | Zendy; Chetan E. Chitnis | Zendy

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Talking to Each Other to Initiate Sexual Differentiation

Author(s) -

Hernando A. del Portillo,

Chetan E. Chitnis

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.05.013

Subject(s) - biology , microbiology and biotechnology , microvesicles , intracellular , gametocyte , vector (molecular biology) , extracellular vesicle , malaria , extracellular , immune system , microrna , cell signaling , immunology , signal transduction , genetics , gene , plasmodium falciparum , recombinant dna

During the blood stage of their life cycle, malaria parasites invade and replicate within host erythrocytes. Some parasites differentiate to form male and female gametocytes, enabling transmission to the insect vector. Two studies by Regev-Rudzki et al. and Mantel et al. reveal an unexpected role for cell-cell communication using extracellular vesicles in triggering the commitment of malaria parasites toward sexual differentiation.

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