SnapShot: Force Spectroscopy and Single-Molecule Manipulation | Zendy

Yeonee Seol | Zendy; Keir C. Neuman | Zendy

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SnapShot: Force Spectroscopy and Single-Molecule Manipulation

Author(s) -

Yeonee Seol,

Keir C. Neuman

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.04.047

Subject(s) - snapshot (computer storage) , biology , force spectroscopy , molecule , computational biology , biophysics , computer science , physics , quantum mechanics , operating system

The deflection of a cantilever is measured using a laser beam and position-sensing detector to obtain force and displacement for both imaging and force spectroscopy. In force spectroscopy, the cantilever is attached to one end of the protein or DNA sample while the other end is immobilized on the surface. The force and position of the tip are measured as the surface is moved away from the tip, providing the force-extension curve of the sample.High spatial resolution (0.5–1 nm); temporal resolution (>1 KHz); high force range (10–10

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