Open AccessDwelling on T Cell Fate Decisions
Author(s) -
Colleen J. Winstead,
Casey T. Weaver
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.04.026
Subject(s) - biology , t cell , t helper cell , acquired immune system , immunology , microbiology and biotechnology , antigen presenting cell , innate lymphoid cell , t cell receptor , immune system
Defining determinants of T cell fate is central to understanding adaptive immunity and the design of effective vaccines. Tubo et al. demonstrate that intrinsic properties of T cell receptor signaling dictate whether CD4 T cells adopt predominantly type 1 helper or follicular helper T cell phenotypes in response to bacterial or viral infection.
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