Radical Host-Specific Therapies for TB | Zendy

Jeroen W. J. van Heijst | Zendy; Eric G. Pamer | Zendy

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Radical Host-Specific Therapies for TB

Author(s) -

Jeroen W. J. van Heijst,

Eric G. Pamer

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.04.019

Subject(s) - proinflammatory cytokine , biology , macrophage , reactive oxygen species , tumor necrosis factor alpha , tuberculosis , host (biology) , immunology , microbiology and biotechnology , disease , mycobacterium tuberculosis , inflammation , ecology , genetics , pathology , medicine , in vitro

Although proinflammatory cytokines such as TNF are critical for containment of tuberculosis, they can also exacerbate disease when produced at high levels. In this issue of Cell, Roca and Ramakrishnan demonstrate that high TNF production induces reactive oxygen species in infected macrophages, ultimately leading to macrophage necrosis and bacterial dissemination.

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