Open AccessOn Your MARK, Get SET(D2), Go! H3K36me3 Primes DNA Mismatch Repair
Author(s) -
Christine K. Schmidt,
Stephen P. Jackson
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.04.018
Subject(s) - biology , chromatin , genetics , histone , dna mismatch repair , computational biology , dna repair , dna , microbiology and biotechnology
Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.
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