SnapShot: Transcription Regulation: Pausing | Zendy

George Fromm | Zendy; Daniel A. Gilchrist | Zendy; Karen Adelman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

SnapShot: Transcription Regulation: Pausing

Author(s) -

George Fromm,

Daniel A. Gilchrist,

Karen Adelman

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.04.011

Subject(s) - biology , nucleosome , histone , mediator , transcription factor ii h , microbiology and biotechnology , general transcription factor , transcription coregulator , rna polymerase ii , transcription factor , transcription (linguistics) , histone code , transcription factor ii d , genetics , histone methylation , transcription preinitiation complex , eukaryotic transcription , dna binding protein , transcription factor ii f , transcription factor ii a , promoter , dna methylation , dna , transcriptional regulation , chromatin remodeling , gene , gene expression , linguistics , philosophy

Productive elongation Modes of P-TEFb Recruitment: TFs (e.g., MYC, NF-κB) Mediator (Med26 subunit or Cdk8 module) Acetylated histones and Brd4 Other elongation factors as part of the superelongation complex CRE DNA-binding transcription factors (TFs) associate with cis-regulatory elements (CRE) to promote assembly of the PIC. TFs can stimulate PIC formation directly through interactions with the Mediator complex and help recruit the general transcription factors (GTFs). TFs also recruit coactivators that can remove nucleosomes from the promoter or modify histone proteins, for example by acetylation (Ac) or methylation (Me).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research