Open AccessA Therapy for Liver Failure Found in the JNK Yard
Author(s) -
Holger Willenbring,
Markus Grompe
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.03.033
Subject(s) - hepatocyte , liver regeneration , druggability , biology , liver injury , liver failure , regeneration (biology) , cancer research , microbiology and biotechnology , medicine , endocrinology , biochemistry , gene , in vitro
In the liver, the hepatocyte mass is kept stable through a tight balance between hepatocyte death and proliferation that is frequently lost upon acute or chronic liver injury. Wuestefeld et al. (2013) now identify a potentially druggable target that enhances hepatocyte proliferation and promotes liver regeneration, thereby preventing liver failure.
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