Higher-Order Assemblies in a New Paradigm of Signal Transduction | Zendy

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Higher-Order Assemblies in a New Paradigm of Signal Transduction

Author(s) -

Hao Wu

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.03.013

Subject(s) - biology , signal transduction , order (exchange) , transduction (biophysics) , microbiology and biotechnology , computational biology , genetics , biophysics , finance , economics

Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecular mechanisms in proximity-driven enzyme activation, threshold behavior, signal amplification, reduction of biological noise, and temporal and spatial control of signal transduction.

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