Open AccessRing around the Ro-sie: RNA-Mediated Alterations of PNPase Activity
Author(s) -
Brian J. Geiss,
Jeffrey Wilusz
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.03.005
Subject(s) - biology , ribonucleoprotein , exoribonuclease , rna , non coding rna , microbiology and biotechnology , genetics , computational biology , rnase p , gene
Chen et al. demonstrate a new way by which noncoding RNAs tailor the function of multicomponent complexes. They show that a noncoding RNA interacts with an exoribonuclease, altering its substrate specificity and enzymatic activity by serving as a ribonucleoprotein scaffold and, perhaps, a gate for entry of the RNA substrate.
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