Nuclear Positioning | Zendy

Gregg G. Gundersen | Zendy; Howard J. Worman | Zendy

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Nuclear Positioning

Author(s) -

Gregg G. Gundersen,

Howard J. Worman

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.02.031

Subject(s) - biology , organelle , nucleus , microbiology and biotechnology , cell nucleus , cytoskeleton , function (biology) , nuclear transport , cell division , nuclear protein , cell , genetics , gene , transcription factor

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet during cell division, migration, and differentiation, it frequently moves to an asymmetric position aligned with cell function. We consider the toolbox of proteins that move and anchor the nucleus within the cell and how forces generated by the cytoskeleton are coupled to the nucleus to move it. The significance of proper nuclear positioning is underscored by numerous diseases resulting from genetic alterations in the toolbox proteins. Finally, we discuss how nuclear position may influence cellular organization and signaling pathways.

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